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Journal of Asian Natural Products Research Volume 17, 2015 - Issue 12
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Articles

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

Wei-Hua YuanKey Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University, Xuzhou221116, China;Natural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USACorrespondence[email protected]
,
Masuo GotoNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USA
,
Kan-Yen HsiehNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USA;Natural Products Research Institute, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Bo YuanKey Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Jiangsu Normal University, Xuzhou221116, China
,
Yu ZhaoNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USA
,
Susan. L Morris-NatschkeNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USA
&
Kuo-Hsiung LeeNatural Product Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC27599-7568, USA;Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, TaiwanCorrespondence[email protected]
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Pages 1239-1244 | Received 06 Aug 2015, Accepted 28 Oct 2015, Published online: 14 Dec 2015
 
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Abstract

One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC50 = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC50 = 5.42 ± 0.167 μM).

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