Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens

Abstract

Two new secoiridoids, swerpatic acid (1) with an unusual C₈ skeleton and swerpalactone (2), were isolated along with ten known compounds (3–12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC₅₀ values of 1.96 and 0.50 mM.

Keywords:

• Swertia patens
• secoiridoids
• swerpatic acid
• swerpalactone
• anti-HBV activity

Acknowledgments

We thank the financial support from the Natural National Science Foundation of China for Distinguished Young Scholars (No. 81025023), the West Light Foundation of the Chinese Academy of Sciences, the Youth Innovation Promotion Association, CAS. And we are also grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.

Disclosure statement

No potential conflict of interest was reported by the authors.