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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 1
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Original Articles

Two new glycosides from Dryopteris fragrans with anti-inflammatory activities

Bing PengBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, China
,
Rui-Feng BaiModern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing100029, China
,
Ping LiBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, China
,
Xu-Yang HanBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, China
,
Hong WangBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, China
,
Chong-Chong ZhuBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, China
,
Zu-Ping ZengBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing100010, ChinaCorrespondence[email protected]
&
Xing-Yun ChaiModern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing100029, China
 show all
Pages 59-64 | Received 20 Aug 2015, Accepted 13 Nov 2015, Published online: 24 Dec 2015
 
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Abstract

Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1–3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively.

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