Antimicrobial acylphloroglucinols from the leaves of Rhodomyrtus tomentosa

Abstract

Phytochemical study on the leaves of Rhodomyrtus tomentosa resulted in the isolation of fourteen compounds including a new acylphloroglucinol, named tomentosone C (1), and a new flavonol glycoside, namely myricetin-3,7,3′-trimethyl ether-5′-O-β-glucopyranoside (2). Their structures were characterized by spectral data interpretation for new structures and in comparison with published data for known compounds. The antimicrobial activity evaluation revealed that 1 and the known acylphloroglucinol rhodomyrtone (3) exhibited significant antimicrobial activity with MIC 3.66 and 1.83 μg ml⁻¹, respectively, toward Staphylococcus aureus, responsible for the antimicrobial activity observed with the n-hexane and EtOAc-soluble fraction of the ethanol extract of R. tomentosa leaves.

Keywords:

• Rhodomyrtus tomentosa
• tomentosone C
• myricetin-3,7,3′-trimethyl ether 5′-O-β-glucopyranoside
• antimicrobial activity

Disclosure statement

No potential conflict of interest was reported by the authors.