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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 9
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Original Articles

Four new diterpenoids isolated from the Euphorbia rapulum

Xiao-Xue LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China
,
Lei ShangSchool of Pharmacy, China Medical University, Shenyang110122, China
,
Chao HuangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang110016, China
,
Xue-Song FengSchool of Pharmacy, China Medical University, Shenyang110122, China
,
Wen LiSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang110016, China
,
Yi ShaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang110016, China
,
Jian HuangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
&
Jin-Hui WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
[email protected]
 show all
Pages 823-830 | Received 12 Nov 2015, Accepted 21 Mar 2016, Published online: 19 Apr 2016
 
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Abstract

Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM.

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