The new steroidal glycosides from the aerial parts of Lepidogrammitis drymoglossoides

Abstract

Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cell lines, and compounds 1 and 2 showed mild activity against all the test cell lines.

Keywords:

• Polypodiaceae
• Lepidogrammitis drymoglossoides
• steroidal glycosides
• cytotoic activity

Acknowledgments

We thank the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ070838), National Natural Science Foundation of China (No. 81403088), China Postdoctoral Science Foundation (No. 2013M541160) for financial supports and construct Program of the Key Discipline in Hunan Province (JSU0713).