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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 9
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Original Articles

Diarylpentanol constituents from the aerial part of Stelleropsis tianschanica

Lei-Ling ShiKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China;Department of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, China
,
Guo-Xu MaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China;Department of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, China
,
Hua-Chun GaoSchool of Pharmaceutical Sciences, Xiamen University, Xiamen361102, China
,
Quan-Cheng ChenSchool of Pharmaceutical Sciences, Xiamen University, Xiamen361102, China
,
Jun-Shan YangKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Beijing100193, China
,
Xiao-Guang JiaDepartment of Natural Medicinal Chemistry, Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi830002, ChinaCorrespondence[email protected]
&
Jing ZhangCollege of Chinese Medicinal Material, Jilin Agricultural University, Changchun130118, ChinaCorrespondence[email protected]
 show all
Pages 885-890 | Received 25 Dec 2015, Accepted 22 Mar 2016, Published online: 12 May 2016
 
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Abstract

Five diarylpentanol derivatives including two new compounds stellerasme A (1), stellerasme B (2) were isolated from the aerial parts of Stelleropsis tianschanica. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity activity against HeLa and KB cell lines, and compound 1 showed selective activities against HeLa cell line with an IC50 value of 7.4 μM.

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