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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 10
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Original Articles

Exopisiod B and farylhydrazone C, two new alkaloids from the Antarctic-derived fungus Penicillium sp. HDN14-431

Ting ZhangKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
Mei-Lin ZhuKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
Guang-Yu SunKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
Na LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
Qian-Qun GuKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
De-Hai LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, China
,
Qian CheKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, ChinaCorrespondence[email protected]
&
Tian-Jiao ZhuKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao266003, ChinaCorrespondence[email protected]
 show all
Pages 959-965 | Received 17 Dec 2015, Accepted 01 Apr 2016, Published online: 01 Jun 2016
 
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Abstract

Two new compounds, exopisiod B (1) and farylhydrazone C (2), together with two known compounds (3–4), were isolated from the Antarctic-derived fungus Penicillium sp. HDN14-431. Their structures including absolute configurations were elucidated by spectroscopic methods and TDDFT ECD calculations. The cytotoxicity and antimicrobial activities of all compounds were tested.

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