Three new alkaloids from the seeds of Nigella glandulifera

Abstract

Three new alkaloids namely 8-(4-hydroxyphenyl)-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one (1), 4-aminonigellidine (2), and N-[(4-hydroxy-2-isopropyl-5-methyl)]phenylurea (3), along with six known ones (4–9), were isolated from the seeds of Nigella glandulifera. The structures of 1–3 were determined through spectroscopic analyses (HRESIMS, 1D/2D NMR). Compound 1 was a rare isoquinolinone alkaloid with phenyl substituted at C-8.

Keywords:

• Ranunculaceae
• Nigella glandulifera
• Semen Nigellae
• alkaloids