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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 3
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Original Articles

Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis

Jia-Ling SongProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China;University of Chinese Academy of Sciences, Beijing100049, China
,
Yao YuanProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China;University of Chinese Academy of Sciences, Beijing100049, China
,
Hai-Bo TanProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China
,
Ri-Ming HuangProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China
,
Hong-Xin LiuProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China
,
Zhi-Fang XuProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, China
&
Sheng-Xiang QiuProgram for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou570650, ChinaCorrespondence[email protected]
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Pages 222-228 | Received 22 Mar 2016, Accepted 15 May 2016, Published online: 14 Jun 2016
 
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Abstract

Two new coumarins, named (±)-euryacoumarin A (1) and 6-demethylobtusinin (2), and one new natural coumarin, named euryacoumarin B (3), along with two known compounds, scopoletin (4) and obtusinol (5), were isolated from the stems of Eurya chinensis. Their structures were elucidated by means of extensive spectroscopic methods and comparison with data reported in the literatures. Compound 1 exhibited significant inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC50 value of 35.64 ± 1.73 μM, and showed marginal antibacterial activities against Bacillus subtilis and B. cereus with MIC values of 50.59 ± 2.12 and 35.42 ± 0.96 μM, respectively.

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