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Journal of Asian Natural Products Research Volume 18, 2016 - Issue 12
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Original Articles

In vitro antimicrobial activity of honokiol against Staphylococcus aureus in biofilm mode

Wen-Li LiDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Xing-Chen ZhaoDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Zi-Wen ZhaoDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Yan-Jun HuangDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Xuan-Zhi ZhuDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Ri-Zeng MengJilin Enrty-exit Inspection and Quarantine Bureau, Changchun130062, China
,
Ce ShiDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
,
Lu YuDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, China
&
Na GuoDepartment of Food Quality and Safety, College of Food Science and Engineering, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun130062, ChinaCorrespondence[email protected]
 show all
Pages 1178-1185 | Received 06 May 2015, Accepted 24 May 2016, Published online: 17 Jun 2016
 
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Abstract

Staphylococcus aureus (S. aureus) can attach to food, host tissues and the surfaces of medical implants and form a biofilm, which makes it difficult to eliminate. The purpose of this study was to evaluate the effect of honokiol on biofilm-grown S. aureus. In this report, honokiol showed effective antibacterial activity against S. aureus in biofilms. S. aureus isolates are capable of producing distinct types of biofilms mediated by polysaccharide intercellular adhesion (PIA) or extracellular DNA (eDNA). The biofilms’ susceptibility to honokiol was evaluated using confocal laser scanning microscopy (CLSM) analysis. The transcript levels of the biofilm-related genes, the expression of PIA, and the amount of eDNA of biofilm-grown S. aureus exposed to honokiol were also investigated. The results of this study show that honokiol can detach existing biofilms, kill bacteria in biofilms, and simultaneously inhibit the transcript levels of sarA, cidA and icaA, eDNA release, and the expression of PIA.

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