Seventeen steroids from the pith of Tetrapanax papyriferus

Abstract

Two new steroidal ketones (1, 2), together with 10 known steroids (3–12) and five known steroidal saponins (13–17), have been obtained from the pitch of Tetrapanax papyrierus. The structures of 1 and 2 were elucidated as 3β-hydroxystigmast-8, 22-diene-7,11-dione and 3β-hydroxystigmast-8-ene-7,11-dione by IR, HR-ESI-MS, 1D and 2D NMR techniques. Except for 4, 14, 15, 16, 13 compounds reported in this paper were isolated from Tetrapanax papyriferus for the first time.

Keywords:

• Araliaceae
• steroidal ketone
• steroidal saponin
• pith
• Tetrapanax papyriferus

Acknowledgements

The authors are thankful to Standardization of Chinese Medicines, SHUTCM for the financial support, and the technology support from Shanghai Institute of Materia Medica, Chinese Academy of Sciences.