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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 3
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Original Articles

Two new phenolic acids from the fruits of Forsythia suspense

Xin-Jia YanCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
,
Jing WenCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China
,
Zheng XiangCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China
,
Dong CaiKey Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China
,
Chong-Ning LvSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China
,
Ying ZhaoCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China
,
Zhong-Yuan QuCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China
,
Yu-Jia LiuCollege of Pharmacy, Harbin University of Commerce, Harbin150076, China
&
Jia-Lin QuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang110016, China
 show all
Pages 254-259 | Received 17 Mar 2016, Accepted 21 Jun 2016, Published online: 20 Jul 2016
 
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Abstract

Two new phenolic acids forsythiayanoside C (1) and forsythiayanoside D (2), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HRESIMS and CD spectrometry. The cytotoxic and antioxidant activities testing showed that compound 2 exhibited free radical scavenging activity.

Acknowledgments

Authors thank Mrs. Ying Peng, Mrs. Wen Li and Mr. Yi Sha of Shenyang Pharmaceutical University for their support in recording of HRESIMS and NMR spectra.

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