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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 4
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Original Articles

New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60

Jian-Song LiLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Hui ZhangDepartment of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, China
,
Shao-Yong ZhangProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China
,
Hai-Yan wangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Ji ZhangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
An-Liang ChenProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China
,
Ji-Dong WangProvincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin’An311300, China;Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, ChinaCorrespondence[email protected]
&
Wen-Sheng XiangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, ChinaCorrespondence[email protected]
 show all
Pages 339-346 | Received 11 Apr 2016, Accepted 07 Jul 2016, Published online: 02 Sep 2016
 
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Abstract

Two new macrocyclic lactones, 4,25-diethyl-4,25-demethyl-milbemycin β3 (1) and 27-formaldehyde-milbemycin β14 (2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.

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