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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 7
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Original Articles

Two new threitol orsellinates from a sea mud-derived fungus, Ascotricha sp. ZJ-M-5

Xiu-Mei XuKey Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang110016, China
,
Dan-Yi LiSchool of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang110016, China
,
Hui-Ming HuaKey Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang110016, China
,
Zhan-Lin LiKey Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
&
Qian LiuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang110016, China
Pages 673-677 | Received 22 Mar 2016, Accepted 23 Aug 2016, Published online: 22 Sep 2016
 
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Abstract

Two new d-threitol orsellinates (1–2) were isolated from the EtOAc extract of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5, cultured in Czapek Dox broth. These two compounds featured in the symmetrical substitution of orsellinic acid or acetic acid, which was established on the basis of 1D and 2D NMR experiments. The characteristic optical rotations enabled the assignment of the absolute configuration.

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