Design, synthesis, cytotoxicities and DNA cleavage activities of dibenzoxepine and isoquinoline derivatives starting from dehydroabietylamine

Abstract

A series of novel hexahydrodibenzoxepine and quinazoline derivatives were designed and synthesized starting from dehydroabietylamine. The cytotoxicities of the compounds against L02 and HepG2 cell lines were investigated. Meanwhile, the plasmid DNA (Escherichia coli) cleavage of several heterocyclic derivatives was studied. These compounds exhibit remarkable activities on plasmid DNA pBR322. Our study provides useful information for developing new and more potent antitumor agents.

Keywords:

• Dehydroabietylamine
• O-heterocyclic
• cytotoxicity
• DNA cleavage activity

Acknowledgments

The generous financial support of the Natural Science Foundation of China (31170536) was gratefully acknowledged. A major project was funded by Natural Science Research of Anhui Province in China (KJ2015A358).