Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 19, 2017 - Issue 5
Submit an article Journal homepage
227
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Steroid glycosides from the starfish Pentaceraster gracilis

Le Thi VienInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Bui Thi NgoanInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Tran Thi Hong HanhInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Le Ba VinhInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Do Cong ThungInstitute of Marine Environment and Resources (IMER), VAST, Haiphong, Vietnam
,
Do Thi ThaoInstitute of Biotechnology (IBT), VAST, Hanoi, Vietnam
,
Nguyen Van ThanhInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Nguyen Xuan CuongInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamCorrespondence[email protected]
,
Nguyen Hoai NamInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Phan Van KiemInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
&
Chau Van MinhInstitute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamCorrespondence[email protected]
 show all
Pages 474-480 | Received 27 May 2016, Accepted 07 Sep 2016, Published online: 05 Oct 2016
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Using combined chromatographic separations, two new steroid glycosides namely pentacerosides A (1) and B (2), and four known compounds were isolated from the methanol extract of the starfish Pentaceraster gracilis. Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, ROESY, and FT-ICR-MS) and by comparing obtained results to the literature values. Among the isolated compounds, only maculatoside (5) showed significant cytotoxic effect against Hep-G2 (IC50 = 16.75 ± 0.69 μM) and SK-Mel2 (IC50 = 19.44 ± 1.45 μM) cell lines and moderate effect on KB (IC50 = 36.53 ± 0.78 μM), LNCaP (IC50 = 39.75 ± 3.34 μM), and MCF7 (IC50 = 47.34 ± 7.01 μM) cell lines.

Acknowledgments

The authors are grateful to the Institute of Chemistry, VAST, for the provision of the spectroscopic instrument.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.