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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 5
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Synthesis and antioxidant activity of curcumin analogs

Qu-Tong ZhengInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
,
Ze-Hua YangInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
,
Liu-Ying YuInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
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Yu-Yan RenInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
,
Qiu-Xia HuangInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
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Qiu LiuInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China;Research Interest Group of Pharmacy, University of South China, Hengyang421001, China
,
Xiang-Yu MaInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China
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Zi-Kang ChenInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, China;Research Interest Group of Pharmacy, University of South China, Hengyang421001, China
,
Zong-Bao WangInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, ChinaCorrespondence[email protected]
&
Xing ZhengInstitute of Pharmacy & Pharmacology, University of South China, Hengyang421001, China;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang421001, ChinaCorrespondence[email protected]
 show all
Pages 489-503 | Received 12 Apr 2016, Accepted 08 Sep 2016, Published online: 03 Oct 2016
 
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Abstract

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure–activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.

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