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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 8
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Articles

Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa

Tian-Tian GuoDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, China
,
Jian-Chun ZhangQuartermaster Research Institute of the General Logistic Department, China-Hemp Research Center, Beijing100082, China
,
Hai ZhangLaboratory Animal Center, Fourth Military Medical University, Xi’an710032, ChinaCorrespondence[email protected]
,
Qing-Chao LiuDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, China
,
Yong ZhaoLaboratory Animal Center, Fourth Military Medical University, Xi’an710032, China
,
Yu-Fei HouDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, China
,
Lu BaiDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, China
,
Li ZhangDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, China
,
Xue-Qiang LiuQuartermaster Research Institute of the General Logistic Department, China-Hemp Research Center, Beijing100082, China
,
Xue-Ying LiuDepartment of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an710032, China
,
Sheng-Yong ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an710032, China
&
Nai-Sheng BaiDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Northwest University, Xi’an710069, ChinaCorrespondence[email protected]
 show all
Pages 793-802 | Received 01 Jun 2016, Accepted 12 Oct 2016, Published online: 16 Nov 2016
 
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Abstract

In this paper, 17 compounds (1–17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and α-cannabispiranol 4’-O-β-D-glucopyranose (2) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. The known compounds 7, 8, 10, 13, 15, and 16 were isolated from Hemp (C. sativa f. sativa) for the first time. Furthermore, compounds 8 and 13 were isolated from the nature for the first time. All isolated compounds were evaluated for cytotoxicity on different tissue-derived passage cancer cell lines through cell viability and apoptosis assay. Among these compounds, compounds 5, 9 and 16 exhibited a broad-spectrum antitumor effect via inhibiting cell proliferation and promoting apoptosis. These results obtained have provided valuable clues to the understanding of the cytotoxic profile for these isolated compounds from Hemp (C. sativa f. sativa).

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