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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 9
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Articles

Lipoxygenase-inhibiting lignans from Clematis mandshurica

Qiang FuSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Chuang ZhouSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Yu MaSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Min YangSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Hai-Mei YuanSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Jiang ChenSchool of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
&
Pei-Xi LiuDepartment of Gastroenterology and Hepatology, Sichuan Provincial People’s Hospital, Chengdu610072, ChinaCorrespondence[email protected]
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Pages 884-889 | Received 08 Jun 2016, Accepted 18 Oct 2016, Published online: 01 Nov 2016
 
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Abstract

The EtOH extract of the roots and rhizomes of Clematis mandshurica afforded two new lignans clemomanshurinane C (1) and clemomanshurinane D (2), and three known compounds (3–5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase.

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