Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 19, 2017 - Issue 9
Submit an article Journal homepage
263
Views
7
CrossRef citations to date
0
Altmetric
Articles

A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5

Chong-Xi LiuLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Shuang-He LiuLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China;Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, China
,
Jun-Wei ZhaoLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Ji ZhangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Xiang-Jing WangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China
,
Jian-Song LiLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, China;Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, China
,
Ji-Dong WangDepartment of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou318000, ChinaCorrespondence[email protected]
&
Wen-Sheng XiangLife Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin150030, ChinaCorrespondence[email protected]
 show all
Pages 924-929 | Received 10 Aug 2016, Accepted 25 Oct 2016, Published online: 13 Nov 2016
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50 values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.