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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 8
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Articles

Three new xanthones from Swertia bimaculata and their anti-5α-reductase activity

Hai-Yan WuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, China
,
Yu ShengKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, China
,
Xue-Qin KanKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, China
,
Lin-Yun MouKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, China
,
Qiu-Feng HuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, ChinaCorrespondence[email protected]
&
Gan-Peng LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming650500, ChinaCorrespondence[email protected]
Pages 774-779 | Received 25 May 2016, Accepted 21 Nov 2016, Published online: 29 Dec 2016
 
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Abstract

Three new xanthones (1–3), together with five known ones (4–8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.

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