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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 2
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Cytotoxic diterpenoids from Pteris ensiformis

Yu-Sheng ShiKey Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education, College of Life Science, Dalian Nationalities University, Dalian116600, China
,
Yan ZhangJiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi154007, China
,
Wen-Zhong HuKey Laboratory of Biotechnology and Bioresources Utilization, The State Ethnic Affairs Commission-Ministry of Education, College of Life Science, Dalian Nationalities University, Dalian116600, China
,
Li-Hong ZhangJiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi154007, China
,
Xi ChenInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing100193, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Branch, Jinghong666100, ChinaCorrespondence[email protected]
,
Ning ZhangJiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi154007, China
,
Guang LiInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Branch, Jinghong666100, China
&
Li-Yan TanDepartment of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi154003, China
 show all
Pages 188-193 | Received 20 Sep 2016, Accepted 13 Dec 2016, Published online: 02 Mar 2017
 
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Abstract

Phytochemistry investigation on Pteris ensiformis led to the isolation of a new ent-kaurane diterpenoid, ent-kaurane-6β,16α-diol-3-one (1), along with five known diterpenoids (2–6) and three known sesquiterpenes (7–9). Their structures were established by means of spectroscopic methods. The ethanol extract and the isolated compounds (1–9) were evaluated for their antitumor activity against three cancer cell lines.

Acknowledgments

Thanks to the support from College of Life Science, Dalian Nationalities University.

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