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Articles

A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba

, , , , , , , & show all
Pages 941-945 | Received 20 Jul 2016, Accepted 19 Dec 2016, Published online: 02 Feb 2017
 

Abstract

A new benzylisoquinoline alkaloid ()-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).

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