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Journal of Asian Natural Products Research Volume 19, 2017 - Issue 10
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Articles

Phenolic acid derivatives with neuroprotective effect from the aqueous extract of Clerodendranthus spicatus

Hai-Chun ZhouAcupuncture and Moxibustion Department, The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin150009, China;Acupuncture and Moxibustion Department, Harbin Medical University, Harbin150001, China
,
Liu YangKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin150040, China
,
Rui-Zhu GuoWenchang Sub Center, Harbin First Aid Center, Harbin150001, China
&
Ji LiSchool Basic Medical Sciences, HUCM, Heilongjiang University of Chinese Medicine, Harbin150040, ChinaCorrespondence[email protected]
Pages 974-980 | Received 22 Aug 2016, Accepted 26 Dec 2016, Published online: 31 Jan 2017
 
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Abstract

Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC50 values of 17.4 and 21.3 μM, respectively.

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