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Abstract
Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.
Acknowlegments
The authors thank the National Natural Science Foundation of China (NNSFC 81630094) and the Beijing Municipal Science and Technology Project (No. Z161100001816047). The authors are grateful to Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College for the spectroscopic data measurements. We also thank Prof. J.B. Li for ESI-MS measurements, Prof. Y.H. Yuan, X.Y. Song for the neuroprotective activity assay, Prof. H. Chen for the hepatoprotective effects test, L. Wang for anti-inflammatory activity assay, and Prof. D.W. Lai for revising the manuscript.