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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 1
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Articles

Three new flavanoids from artificially induced dragon’s blood of Dracaena cambodiana

Fei-Xiang LiKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, China
,
Hui WangKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, China
,
Cui-Juan GaiKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, China
,
Hui-Qin ChenKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, China
,
Wei LiKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, China
,
Wen-Li MeiKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, ChinaCorrespondence[email protected]
&
Hao-Fu DaiKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou571101, ChinaCorrespondence[email protected]
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Pages 55-61 | Received 14 Oct 2016, Accepted 20 Apr 2017, Published online: 09 Jun 2017
 
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Abstract

Three new flavanoids, (2R)-7,4′-dihydroxy-8-methylflavan (1), (2R)-7,4′-dihydroxy-6-methylflavan (2), and (3R)-7,3′,4′-trihydroxyhomoisoflavan (3), together with seven known compounds (4–10), were isolated from artificially induced dragon’s blood of Dracaena cambodiana, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 2 exhibited weak cytotoxicity against BEL-7402 cells line with the IC50 value of 39.2 μM. In addition, compound 3 showed significant acetylcholinesterase (AChE) inhibitory activity.

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