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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 6
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Articles

A new steroidal saponin from Polygonatum sibiricum

Hong-Yang ZhangCenter of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin150076, China;Key Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, China
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Wei-Cheng HuJiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Haiyin Normal University, Huaian223300, China;Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Haiyin Normal University, Huaian223300, China
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Guo-Xu MaKey Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, China
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Nai-Liang ZhuKey Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, China
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Xiao-Bo SunKey Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, China
,
Hai-Feng WuKey Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, ChinaCorrespondence[email protected]
&
Xu-Dong XuKey Laboratory of Bioactive Substance and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100193, ChinaCorrespondence[email protected]
 show all
Pages 586-592 | Received 15 Feb 2017, Accepted 02 Jul 2017, Published online: 23 Nov 2017
 
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Abstract

A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2–5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3–5 showed significant cytotoxicity against HepG2 cell lines with IC50 values of 14.2, 12.1 and 8.5 μM, respectively.

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