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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 8
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The caffeoyl phenylethanoid glycosides from Lindernia ruellioides and their anti-HBV effects

Jing-Chen WeiCollege of Pharmacy, Guilin Medical University, Guilin541004, China;Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin541001, China
,
Peng-Cheng WangCollege of Pharmacy, Guilin Medical University, Guilin541004, China
,
Xian-Li ZhouCollege of Pharmacy, Guilin Medical University, Guilin541004, China
,
Kun TangDepartment of Pharmacy, Affiliated Hospital of Guilin Medical University, Guilin541004, China
,
Qin LuoCollege of Pharmacy, Guilin Medical University, Guilin541004, China
,
Qin XuCollege of Pharmacy, Guilin Medical University, Guilin541004, China;Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin541001, China
,
Xue-Jiao ChenCollege of Pharmacy, Guilin Medical University, Guilin541004, China
,
Cheng-Qin LiangCollege of Pharmacy, Guilin Medical University, Guilin541004, ChinaCorrespondence[email protected]
&
Xu ChenCollege of Pharmacy, Guilin Medical University, Guilin541004, ChinaCorrespondence[email protected]
 show all
Pages 757-762 | Received 01 May 2017, Accepted 16 Jul 2017, Published online: 25 Sep 2017
 
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Abstract

Five caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC50 values of 54.87, 30.74, and 69.02 μM for HBsAg and 26.70, 5.17, and 7.08 μM for HBeAg, respectively.

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