Abstract
Chemical study on the ethanolic extract generated from the aerial parts of Croton kongensis led to the isolation of three new 8,9-seco-ent-kaurane diterpenoids, kongeniods A‒C (1‒3), together with seven known analogs (4–10). The structures of these compounds were assigned by spectroscopic data analysis. The vitro cytotoxic tests showed that compounds 1–3 exhibited strong activities against HL-60 cell lines with IC50 values of 0.47, 0.58, and 1.27 μM, respectively.
Acknowledgments
Financial support of the National Natural Science Foundation (No. U1302222) of China is gratefully acknowledged. We thank Prof. S. M. Huang from Department of Biology, Hainan University, for the identification of the plant material.