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Articles

The chemical constituents from Urtica fissa leaves

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Pages 709-718 | Received 21 May 2017, Accepted 18 Sep 2017, Published online: 03 Oct 2017
 

Abstract

A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (419), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC50 values less than 4.0 μM.

Acknowledgements

The authors are really grateful to Dr. Bona Dai of the Instrumental Analysis Center of Shanghai Jiao Tong University, for the measurements of NMR.

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