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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 12
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Articles

A new highly oxygenated pregnane and two new 5-hydroxymethylfurfural derivatives from the water decoction of Poria cocos

Ting ChenThe MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China;Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai201203, China
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Yong-Jun KanInstitute of Drug Research, Fujian Academy of Chinese Medicine, Fuzhou350003, China
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Gui-Xin ChouThe MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China;Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai201203, ChinaCorrespondence[email protected]
&
Cheng-Gang ZhangThe MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China;Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai201203, China
Pages 1101-1107 | Received 22 Jun 2017, Accepted 18 Sep 2017, Published online: 09 Oct 2017
 
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Abstract

A new highly oxygenated pregnane steroid, pregn-7-ene-2β,3α,15α,20-tetrol (1) and two new 5-hydroxymethylfurfural derivatives, (5-formylfuran-2-yl)methyl 2-hydroxypropanoate (2) and (5-formylfuran-2-yl)methyl 2-(4-hydroxyphenyl)acetate (3), together with four known compounds, were isolated from the water decoction of Poria cocos. Their structures were established on the basis of extensive spectroscopic analysis. Compound 1 showed moderate inhibitory activity and a known compound (3S,6S)-3-[(1R)-1-hydroxyethyl]-6-(phenylmethyl)-2,5-piperazinedione (5) showed weak inhibitory activity against α-glucosidase, respectively.

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