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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 9
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Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii

Dan ZhaoSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China
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Ming-Xu TangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China
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Shan-Shan SuTesting Laboratory, Qinghai Entry Exit Inspection and Quarantine Bureau, Xining810000, China
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Xiao-Jie LuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China
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Yu-Bo WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China;Schoolof Pharmacy, Jinzhou Medical University, Jinzhou121001, China
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Shao-Fei ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China
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Hai-Feng WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, China
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Gang ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
&
Yue-Hu PeiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
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Pages 852-859 | Received 18 Jul 2017, Accepted 22 Oct 2017, Published online: 03 Nov 2017
 
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Abstract

Two new 13,14:14,15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3–6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6 μM, respectively, compared to the positive control 5-fluorouracil (6.4 μM).

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