Cytotoxic ring A-seco triterpenoids from the stem bark of Dysoxylum lukii

Abstract

A chemical investigation of the 70% ethanol extract from the stem bark of Dysoxylum lukii afforded three new ring A-seco triterpenoids, dysoxylukiines A–C (1–3). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties. Consequently, compound 3 exhibited modest cytotoxic activities against four osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, and M663) with IC₅₀ values less than 10 μM.

Keywords:

• Dysoxylum lukii
• Meliaceae
• triterpenoids
• cytotoxicity