Abstract
A series of asiatic acid derivatives were synthesized and their cytotoxicities in vitro against two cancer cell lines (HepG2 and SGC7901) were evaluated by MTT assay. The results showed that compounds I2, I6, and II6 have more potent anticancer activity than that of the positive control drug paclitaxel. The interactions between the compounds I2, I6, and II6 and survivin were also studied by docking simulations.
Acknowledgments
The authors thank the Project-sponsored by the Natural Science Foundation of Liaoning Province, the National Natural Science Foundation of China and Scientific Research Project of the Shenyang Science and Technology Board and Shenyang Pharmaceutical University for the tool and technology assistance in docking studies.