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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 1
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Articles

C-glycosides from the stems of Calophyllum membranaceum

Ling-Juan ZhuKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China
,
Sen YiKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China
,
Xue LiKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China
,
Hai-Feng ChenSchool of Pharmaceutical Sciences, Xiamen University, Xiamen361102, China
,
Meng MingKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;School of Public Health, Shenyang Medical College, Shenyang110034, China
,
Xue ZhangKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
[email protected]
&
Xin-Sheng YaoKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, China;Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, China
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Pages 49-54 | Received 20 Oct 2017, Accepted 22 Nov 2017, Published online: 06 Dec 2017
 
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Abstract

Three new C-glycosides, calophymembransides D-F (1–3), were isolated from the stems of Calophyllum membranaceum Gardn. et Champ.. The structures were assigned on the basis of spectroscopic data. RXRα transcriptional inhibition and α-glucosidase inhibition assays indicated that all the isolates were inactive.

Acknowledgment

The authors thank Prof. Song-Ji Wei, at Guangxi University of Chinese Medicine, Guangxi province, China for the botanical collection and identification. Thanks are also given to the Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, for measuring the HRESIMS data.

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