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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 3
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Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana

Sabrin Ragab Mohamed IbrahimDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah30078, Saudi Arabia;Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut71526, EgyptCorrespondence[email protected]
[email protected]
,
Gamal Abdallah MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah21589, Saudi Arabia;Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut71524, Egypt
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Mahmoud Abdelkhalek ElfakyDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah21589, Saudi Arabia
,
Rwaida Adel Al HaidariDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah30078, Saudi Arabia
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Mohamed Fathalla ZayedDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah30078, Saudi Arabia;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
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Amal Abd-Elmoneim El-KholyDepartment of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah30078, Saudi Arabia;Department of Clinical Pharmacy, Faculty of Pharmacy, Ain-Shams University, Cairo11566, Egypt
&
Amgad Ibrahim Mansour KhedrDepartment of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said42526, Egypt
 show all
Pages 291-297 | Received 03 Jul 2017, Accepted 28 Dec 2017, Published online: 07 Jan 2018
 
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Abstract

A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3), β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC50s 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).

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