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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 5
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Articles

Polyketides from the fungus Penicillium decumbens

Sheng LinDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China
,
Yu-Zhuo WuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, China
,
Ke-Yv ChenDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China
,
Ji YeDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China
,
Xian-Wen YangDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, China
&
Wei-Dong ZhangDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai200433, ChinaCorrespondence[email protected]
Pages 445-450 | Received 10 Oct 2017, Accepted 02 Jan 2018, Published online: 17 Jan 2018
 
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Abstract

Two new polyketides, 3,11-dihydroxy-6,8-dimethyldodecanoic acid (1) and trichopyrone B (2), together with two known polyketides, sorbicillin (3) and penicillone A (4), have been isolated from the cultures broth of the fungus Penicillium decumbens. Their structures were elucidated by extensive spectroscopic analysis. All isolated compounds were evaluated for their antibacterial and cytotoxic activities. Of these, compound 3 showed antifungal activity toward Candida albicans Y0109 with a MIC value of 50 μM. Moreover, compounds 3 and 4 exhibited selective cytotoxicity against the human hepatocellular carcinoma (QGY-7703) cell line with the IC50 values of 32.5 and 22.8 μM, respectively.

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