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Journal of Asian Natural Products Research Volume 20, 2018 - Issue 5
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Articles

New secoiridoids from the fruits of Ligustrum lucidum

Zuo-Cheng QiuGuangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou510632, China
,
Xiao-Xiao ZhaoGuangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou510632, China
,
Qing-Chang WuGuangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou510632, China
,
Jian-Wu FuKey Laboratory of Standard Material in Natural Medicine of Guangdong Province, Guangzhou510530, China
,
Yi DaiGuangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou510632, China;Key Laboratory of Standard Material in Natural Medicine of Guangdong Province, Guangzhou510530, ChinaCorrespondence[email protected]
,
Man-Sau WongShenzhen Research Institute of the Hong Kong Polytechnic University, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen518057, China
&
Xin-Sheng YaoGuangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou510632, China;Key Laboratory of Standard Material in Natural Medicine of Guangdong Province, Guangzhou510530, China;College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
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Pages 431-438 | Received 08 Jan 2018, Accepted 15 Mar 2018, Published online: 28 Mar 2018
 
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Abstract

Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.

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