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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 7
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Articles

Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides

Cheng-Shi JiangSchool of Biological Science and Technology, University of Jinan, Jinan250022, ChinaORCID Iconhttp://orcid.org/0000-0002-2760-7596
ORCID Icon,
Yin-Yin WangSchool of Biological Science and Technology, University of Jinan, Jinan250022, China
,
Jin-Tong SongSchool of Biological Science and Technology, University of Jinan, Jinan250022, China
&
Jin-Hai YuSchool of Biological Science and Technology, University of Jinan, Jinan250022, ChinaCorrespondence[email protected]
Pages 619-626 | Received 19 Nov 2017, Accepted 08 Apr 2018, Published online: 28 May 2018
 
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Abstract

Three new acylphloroglucinols (1–3) and four known biosynthetically related analogs (4–7) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 1–7 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer’s diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure–activity relationship was also discussed.

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