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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 7
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Articles

Sesquiterpenoids from the roots of Croton crassifolius

Jin-Long TianKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Chen-Xi LiKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Xin-Yue ShangKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Xue-Wen HouKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Yan ZhangKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Ling-Zhi LiKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
,
Xiao-Xiao HuangKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China;Chinese People’s Liberation Army 210 Hospital, Dalian, ChinaCorrespondence[email protected]
&
Shao-Jiang SongKey Laboratory of Structure-Based Drug Design and Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
 show all
Pages 666-672 | Received 12 Jan 2018, Accepted 12 Apr 2018, Published online: 10 Jun 2018
 
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Abstract

Phytochemical investigation of Croton crassifolius roots afforded five sesquiterpenes (1–5), including two new sesquiterpenes 6S-hydroxy-cyperenoic acid (1) and crassifterpenoid A (5), together with three known compounds (2–4). The structures of the new compounds were determined by comprehensive spectroscopic methods, and their absolute configurations were determined by quantum chemical ECD calculation. Crassifterpenoid A (5) is the first germacrane-type sesquiterpene isolated from C. crassifolius, which enriched the diversity of chemical constituents in Croton crassifolius. In addition, the cytotoxicities of all compounds against human liver cancer lines HepG2 and Hep3B were determined, but none showed significant activity.

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