Design, synthesis, and antitumor activity of desmosdumotin C analogues

Abstract

Desmosdumotin C (Des C), a natural product isolated from the roots of Desmos dumosus, has shown good antitumor activity. A three dimensional quantitative structure-activity relationship (QSAR) study using the comparative molecular field analysis (CoMFA) method was performed on 32 Des C analogues. Based on the QSAR, 18 new Des C analogues were designed and synthesized. An efficient three-step synthetic strategy toward Des C and its analogues was developed from commercial available 2, 4, 6-trihydroxyacetophenone. All synthesized compounds were evaluated against a panel of human cancer cell lines and showed ED₅₀ values ranging from 1.1 to 25.1 µΜ.

Keywords:

• QSAR
• CoMFA
• desmosdumotin C analogues
• antitumor
• human cancer cell Lines

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This project was supported by the National Natural Science Foundation of China (No. 81072546, No. 81470156).