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Journal of Asian Natural Products Research Volume 21, 2019 - Issue 5
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Original Articles

Platycosides P and Q, two new triterpene saponins from Platycodon grandiflorum

Lu QiuCollege of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Yu XiaoCollege of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Yao-Qi LiuCollege of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China
,
Lian-xin PengCollege of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China;Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture, Chengdu610106, China
,
Wan LiaoState Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu611137, China
&
Qiang FuCollege of Pharmacy and Bioengineering, Chengdu University, Chengdu610106, China;Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture, Chengdu610106, ChinaCorrespondence[email protected]
Pages 419-425 | Received 05 Apr 2018, Accepted 10 Jun 2018, Published online: 02 Jul 2018
 
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Abstract

The EtOH extract of the roots of Platycodon grandiflorum afforded two new triterpene saponins platycoside P (1) and platycoside Q (2). Their structures were elucidated based on spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against LPS-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed inhibitory activity with the inhibition ratios (%) of 38.6 and 44.1 at 50 μM, respectively.

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