Cytotoxic lanostane triterpenoids from the stems of Schisandra glaucescens

Abstract

Phytochemical investigation on the stems of Schisandra glaucescens resulted into the isolation of three new lanostane triterpenoids, 12-hydroxyschiglausin B (1), 12-hydroxykadsuphilactone B (2), and 20R-hydroxyschinalactone C (3). Structural elucidation of all the compounds was accomplished by spectral methods. The isolated compounds were tested in vitro for cytotoxic activities. As a result, triterpenoids 1 and 2 showed cytotoxic activities for all six tested tumor cell lines with IC₅₀ values less than 15 μM.

Keywords:

• Schisandra glaucescens
• Schisandraceae
• lanostane triterpenoids
• cytotoxicity