Iridoid glycosides from the fruits of Cornus officinalis

Abstract

Four new iridoid glycosides named cornusphenosides A–D (1–4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1–4 were also assessed in vitro.

Keywords:

• Cornaceae
• Cornus officinalis
• iridoid glycosides
• cornusphenosides A–D
• isolation
• structural elucidation

Disclosure statement

There are no potential conflicts of interest to declare.

Additional information

Funding

The authors gratefully acknowledge financial support from the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (Grant No. KZ201811417049) and Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201811417008).