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Abstract
Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis. Ginsenoside Rg1 is a major active ingredient in processed Panax ginseng, which is proved to elicit biological effects. We hypothesized the beneficial effect of Rg1 on APAP-mediated hepatotoxicity was through Nrf2/ARE pathway. The study was conducted in cells and mice, comparing the actions of Rg1. Rg1 significantly improved cell survival rates and promoted the expression of antioxidant proteins. Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway. Expression of Nrf2 has a certain cell specificity.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (Grant No. 81274122, 81260650, 81373997, 81373510, 81473570, 81560685, 81573640, 81573636, and U1402221), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) (IRT1007), Beijing Natural Science Foundation (7131013), Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), PUMC Youth Fund (3332016058), the Fundamental Research Funds for the Central Universities (2014RC03, 2016RC350002), Key Research and Development Project of Hunan Province (2015SK2029-1), and the Scientific Research Foundation of the Higher Education Institutions of Hunan Province (15K091).