Bioactive megastigmane glucosides and monoterpenes from Lyonia ovalifolia

Abstract

Three new megastigmane glucosides (1–3) and two new monoterpenes (4–5), together with 14 related known compounds (6–19) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of the new compounds were determined by extensive MS, NMR, CD experiments and chemical methods. Compounds 2, 6, and 18 displayed potent antiviral activity against Coxsackie B3, with IC₅₀ values between 6.4 and 14.6 µM. Additionally, compounds 6, 10, and 11 exhibited noteworthy anti-inflammatory activities, with inhibition rates ranging from 54.55% to 83.33% under the concentration of 10⁻⁵ M.

Keywords:

• Ericaceae
• Lyonia ovalifolia
• megastigmane glucosides
• monoterpenes
• antiviral activity
• anti-inflammatory activity

Acknowledgments

The authors are grateful to the Department of Instrumental Analysis of Peking Union Medical College for the spectroscopic measurements.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by grants from the National Natural Science Foundation of China (Nos. 81573321 and 21572274).