149
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Two new compounds from the roots of Scrophularia ningpoensis and their anti-inflammatory activities

ORCID Icon, , , , , & show all
Pages 1083-1089 | Received 06 Feb 2018, Accepted 16 Aug 2018, Published online: 06 Jan 2019
 

Abstract

Aiming to investigate the bioactive constituents with anti-inflammatory activity from the roots of Scrophularia ningpoensis, two new compounds (1 and 3) were isolated from the extract of the roots of the plant. Their structures were elucidated on the basis of spectral analyses (UV, IR, NMR, and MS spectroscopy), as well as experimental and calculated electronic circular dichroism (ECD) analyses. All of the isolates were tested for their anti-inflammatory properties in terms of suppressing the production of NO in lipopolysaccharide-induced BV2 cells. Compound 2 exhibited stronger anti-inflammatory effects (77.65%) than the positive control curcumin (69.75%) at 10 μM.

Graphical Abstract

This research was financially supported by the “Hospital Youth Fund of The First Affiliated Hospital of Zhengzhou University”.

Additional information

Funding

This research was financially supported by the “Hospital Youth Fund of The First Affiliated Hospital of Zhengzhou University”

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.