New abietane diterpenoid glucosides from underground parts of Isodon taliensis

Abstract

Two new abietane diterpenoid glucosides, talienosides A and B (1 and 2), along with four known compounds (3 – 6), were isolated from the ethyl acetate soluble portion of 70% acetone extract of the underground parts of Isodon taliensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. The two new compounds were tested for their bioactivities against malaria and diabetes by β-hematin formation inhibition and α-glycosidase inhibition experiments, respectively. However, only 2 showed weak β-hematin formation inhibitory activity.

Keywords:

• Labiatae
• Isodon taliensis
• abietane diterpenoid glucosides
• β-hematin formation inhibition activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The work was financially supported by the National Natural Science Foundation of China [Grant number 81460532].