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Abstract
A new oxacyclododecindione-type macrolactone, (13R,14S,15R)-13-hydroxy-14-deoxyoxacyclododecindione (1), has been obtained from the solid cultures of the fungus Exserohilum rostratum, a fungal strain endophytic in Gymnadenia conopsea. Its structure, including the absolute configuration, was extensively established by 1D and 2D NMR data, the modified Mosher method, and a combination of experimental and theoretically calculated electronic circular dichroism (ECD) spectra. Compound 1 showed weak selective cytotoxicity against the A549 lung cell line with an IC50 value of 9.2 µM.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was financially supported by the National Natural Science Foundation of China (NNSFC; Nos. 81522050, 81773589, 81760783), Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee (no. KZ201811417049), the Science and Technology program of Qinghai (no. 2018-ZJ-739), the National Science and Technology Project of China (no.2018zx09711001-001), and the CAMS Innovation Fund for Medical Science (CIFMS; No. 2017-I2M-3-010).